منابع مشابه
Enzymatic mechanism of the tumoricidal action of 4-iodo-3-nitrobenzamide.
Activation of the prodrug 4-iodo-3-nitrobenzamide critically depends on the cellular reducing system specific to cancer cells. In non-malignant cells, reduction of this prodrug to the non-toxic amine occurs by the flavoprotein of complex?I of mitochondria receiving Mg2+-ATP-dependent reducing equivalents from NADH to NADPH via pyridine nucleotide transhydrogenation. This hydride transfer is def...
متن کاملEvaluating aziridinyl nitrobenzamide compounds as leishmanicidal prodrugs.
Many of the nitroaromatic agents used in medicine function as prodrugs and must undergo activation before exerting their toxic effects. In most cases, this is catalyzed by flavin mononucleotide (FMN)-dependent type I nitroreductases (NTRs), a class of enzyme absent from higher eukaryotes but expressed by bacteria and several eukaryotic microbes, including trypanosomes and Leishmania. Here, we u...
متن کامل4-(4-Nitrostyryl)-N,N-diphenylaniline
In the triaryl-amine group of the title compound, C(26)H(20)N(2)O(2), the N atom adopts an approximately trigonal-planar geometry, lying 0.046 (5) Å from the plane P defined by its three neighbouring C atoms; the benzene and two terminal phenyl rings are twisted by 37.4 (1), 31.4 (1) and 47.8 (1)°, respectively from plane P. In the trans-stilbene fragment, the two benzene rings form a dihedral ...
متن کاملN,4-Dimethyl-N-(4-nitrobenzyl)benzenesulfonamide
In the title compound, C(15)H(16)N(2)O(4)S, there is a dihedral angle of 63.30 (8)° between the nitro-benzyl and benzene rings, which are separated by a sulfonamide unit The crystal packing is stabilized by a C-H⋯O inter-action.
متن کاملN-(4-Chlorophenyl)-N′-(4-methylphenyl)succinamide
The asymmetric unit of the title compound, C(17)H(17)ClN(2)O(2), contains one half-mol-ecule with a center of symmetry at the mid-point of the central C-C bond. The dihedral angle between the benzene ring and the adjacent NH-C(O)-CH(2) group is 39.9 (1)°. The methyl and Cl groups are disordered with respect to the para-positions of the benzene ring, with site-occupation factors of 0.5 each. In ...
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ژورنال
عنوان ژورنال: Acta Crystallographica Section E Structure Reports Online
سال: 2010
ISSN: 1600-5368
DOI: 10.1107/s1600536810036366